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MDR-1 GENE MUTATION - IMPORTANT - PLEASE READ

Many herding dog breeds are afflicted with a mutation of the multi-drug resistance (mdr1) gene. This gene encodes a protein (P-glycoprotein) that is responsible for removing certain drugs and toxins from the brain. Dogs that carry the mdr1 genetic defect cannot rid their brains of the problem drugs. The result is a neurotoxic buildup that can cause abnormal neurological symptoms and/or death.

Breeds known to carry the mdr1 mutation include Australian Shepherds of all sizes, Collies and collie breeds, English Shepherds, Longhaired Whippets, McNabs, Old English Sheepdogs, Shetland Sheepdogs, and Silken Windhounds. Research has shown that three of every four Collies have at least one copy of the mutated gene.

If you have a breed that can be afflicted by this mutation, IT CAN KILL YOUR DOG.

Please see BusterAlert.org

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